Round Spermatid Injection (ROSI)
Who Can Benefit from the ROSI Method?
The ROSI technique is not a magical solution; it must be carried out with precision and care by experienced professionals in reputable centers. When applied to the right patients, it provides a hopeful option for couples who otherwise might not have the opportunity to have children. We have successfully achieved this technique in Albania. Pregnancy rates with ROSI are typically around 20%, marking a significant step forward for couples who had previously no chance of conceiving.
What is the ROSI Technique?
ROSI is a method of assisted reproduction where immature male reproductive cells, called round spermatids, are directly injected into an egg for fertilization. This technique can be a viable option for couples facing sperm production issues in men.
Normally, spermatids mature into sperm cells through several stages. However, in some men, this process is incomplete, leading to round spermatids. In the ROSI technique, these immature spermatids are extracted and injected into the egg cell using specialized techniques in laboratory.
ROSI is typically applied during in vitro fertilization (IVF), where the woman’s eggs are collected, and fertilization occurs in the lab. Unlike conventional IVF, ROSI uses immature spermatids to achieve fertilization, making it an option for men with issues in sperm maturation or other sperm production problems.
Success Stories with ROSI
For many couples, reproductive health is one of the most cherished aspects of their lives, but it can also be a journey full of challenges. IVF Vision stands out for its innovation and the promising results achieved with the ROSI method. The technique is a solution for couples with sperm maturation issues, providing an opportunity for men to become fathers when they had little to no chance otherwise.
By using round spermatids, the ROSI method allows for fertilization in a laboratory environment, increasing the chances of successful conception for those with sperm maturation problems.
How and Who Can Receive ROSI Treatment?
The ROSI technique is typically considered for couples who have a low chance of conceiving naturally due to issues in sperm production. It is particularly beneficial for men with sperm maturation disorders, obstructive azoospermia, or genetic issues affecting sperm production.
ROSI is applied by injecting round spermatids into an egg cell using specialized techniques. This method allows spermatids that haven’t fully matured to gain the ability to fertilize the egg. The ROSI method can be considered in the following cases:
- Sperm Maturation Problems: In cases where sperm maturation doesn’t occur normally, ROSI offers a solution using immature spermatids.
- Obstructive Azoospermia: For men who have a blockage preventing sperm from being released during ejaculation, ROSI may increase fertilization chances.
- Genetic Issues: For men with genetic disorders that prevent normal sperm production, ROSI may be a viable option.
- Low Chance of Fatherhood: Men with little to no chance of becoming fathers can benefit from the ROSI method to increase their chances of success.
Can ROSI Be Performed on Patients with Genetic Problems?
Genetic conditions, such as Klinefelter syndrome, can pose significant reproductive challenges. However, advanced reproductive technologies like the ROSI method offer hope for such patients.
Klinefelter syndrome is a genetic disorder where men may have smaller-than-normal testicles, affecting their ability to produce sperm. ROSI can be an important step for these patients. Before starting ROSI, general health, hormone levels, and testicular health are thoroughly assessed. The treatment is adapted to the individual needs of the patient, ensuring the best possible outcome.
IVF Vision’s expert team carefully evaluates each case to provide personalized care, offering couples a hopeful path forward.
ROSI Technique Success Rate
The success rates of the ROSI technique are 5% -10 %. As experience grows, success rates are expected to rise even further.
ROSI is particularly useful for azoospermic men who have not been able to obtain sperm cells through previous methods like microTESE.
While ROSI is an essential treatment option for male infertility, it’s not suitable for every patient. The decision to proceed is made based on genetic, hormonal, and clinical evaluations by a urologist,gynecologists and embryologists.
The process involves combining the egg and spermatid through microinjection, followed by embryo transfer to the woman’s uterus. Pregnancies resulting from ROSI are closely monitored, though they generally follow the same process as conventional pregnancies.
At IVF Vision, we support couples through every step of their ROSI journey. Our experienced team explains all aspects of the process, ensuring that couples feel informed and supported throughout treatment.